Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans
Top Cited Papers
- 11 May 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 292 (5519), 1171-1175
- https://doi.org/10.1126/science.1060036
Abstract
Telomere proteins from ciliated protozoa bind to the single-stranded G-rich DNA extensions at the ends of macronuclear chromosomes. We have now identified homologous proteins in fission yeast and in humans. These Pot1 (protection oftelomeres) proteins each bind the G-rich strand of their own telomeric repeat sequence, consistent with a direct role in protecting chromosome ends. Deletion of the fission yeastpot1 + gene has an immediate effect on chromosome stability, causing rapid loss of telomeric DNA and chromosome circularization. It now appears that the protein that caps the ends of chromosomes is widely dispersed throughout the eukaryotic kingdom.Keywords
This publication has 32 references indexed in Scilit:
- Cdc13 Delivers Separate Complexes to the Telomere for End Protection and ReplicationCell, 2001
- Est1 and Cdc13 as Comediators of Telomerase AccessScience, 1999
- Normal human chromosomes have long G-rich telomeric overhangs at one endGenes & Development, 1997
- The terminal DNA structure of mammalian chromosomesThe EMBO Journal, 1997
- Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere ShorteningCell, 1997
- Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 CheckpointMolecular and Cellular Biology, 1995
- Saccharomyces telomeres acquire single-strand TG1–3 tails late in S phaseCell, 1993
- Cloning and expression of genes for the Oxytricha telomere-binding protein: Specific subunit interactions in the telomeric complexCell, 1991
- Telomere proteins: Specific recognition and protection of the natural termini of Oxytricha macronuclear DNACell, 1986
- All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus.Proceedings of the National Academy of Sciences, 1981