Nitrogen Mustard: Diminution of Toxicity in Axenic Mice
- 28 June 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 140 (3574), 1400-1401
- https://doi.org/10.1126/science.140.3574.1400
Abstract
Axenic, or germ-free, mice are more resistant to the delayed lethal effect of nitrogen mustard than normal mice. The resistance is most striking when mustard is administered at pH 2.0. The finding supports the hypothesis that intestinal bacteria play an important role in the systemic toxicity of nitrogen mustard.Keywords
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