Propagation of a Strain of Egg-Adapted Distemper Virus in Suckling Mice.

Abstract

Two separate lines of the FXNO strain of egg-adapted canine distemper virus were passed intracerebrally in suckling mice 18 and 10 times, respectively. After the 7th passage central nervous system involvement became quite prominent and severe. The time of the first nervous disturbance decreased progressively in both lines. In ovo, neutralization tests and ferret protection tests established the identity of the mouse passaged agent.