The isolation and chemical properties of trichothecin, an antifungal substance from Trichothecium roseum Link

Abstract

The isolation in crystalline form of an antifungal substance from T. roseum was done with chloroform extraction and chromatography on alumina. The material was assayed by its effect on spore-germination of Penicillium digitatum. The formula C15H18O4 or C15H20O4 is suggested. Trichothecin is active against Fungi Imperfecti, Zygomycetes and Ascomycetes and inactive against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli.