The role of the left end of the H‐2b haplotype in the male‐specific cytotoxic T cell response

Abstract

The male‐specific cytotoxic T cell response was tested in various mouse strains. We found that priming with lo⁷ nonirradiated or 2 × 10⁷ X‐irradiated cells (2000 Rad) was similarly effective in B 6 mice. We have avoided possible allogeneic effects due to priming F₁ hybrids with parental cells and tested all mice after the same time interval for generation of male‐specific cytotoxic T lymphocytes in vitro. Under these conditions, we found an absolute requirement for H‐2^b gene products, encoded left of B, in order to see male‐specific responses.