Effect of alterations in extracellular fluid volume on urinary kallikrein in the conscious rat.
- 1 September 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 4 (5), 625-633
- https://doi.org/10.1161/01.hyp.4.5.625
Abstract
The effect of alterations in extracellular fluid volume (ECV) and solute concentration on excretion of urinary kallikrein was examined in conscious Sprague-Dawley rats. Animals were given infusions of either dextrose and water, saline, or albumin according to a variety of protocols. These were designed to evaluate possible relationships between excretion of kallikrein, volume, sodium, and potassium. A reproducible pattern of kallikrein excretion was noted in all volume expanded groups. This consisted of a short lived increase during the initial hour of expansion with a subsequent fall to lower levels than baseline and a gradual recovery. To define the role of aldosterone in these studies, an adrenalectomized group and a group of appropriately prepared sham controls were expanded with saline. Adrenalectomy did not effect this pattern. We postulate a tubular "washout" phenomenon as the etiology of these observations. Results of these studies fail to demonstrate a consistent relationship between urinary volume, sodium, or potassium and the simultaneous amount of kallikrein found in the urine.This publication has 30 references indexed in Scilit:
- Feedback-mediated reduction of glomerular filtration rate during infusion of hypertonic salineKidney International, 1981
- Kallikrein localization in rodent salivary glands and kidney with the immunoglobulin-enzyme bridge technique.Journal of Histochemistry & Cytochemistry, 1979
- Circadian changes in plasma renin activity and plasma aldosterone concentration in two-kidney hypertension rats.Hypertension, 1979
- Urinary kallikrein and changes in endogenous aldosterone in the ratEuropean Journal of Clinical Investigation, 1977
- Studies on rat renal cortical cell kallikrein I. Separation and measurementBiochimica et Biophysica Acta (BBA) - General Subjects, 1975
- The role of the collecting duct in the regulation of excretion of sodium and other electrolytesKidney International, 1974
- A Comparison of the Segmental Analysis of Sodium Reabsorption during Ringer's and Hyperoncotic Albumin Infusion in the RatJCI Insight, 1973
- The relative contributions of reabsorptive rate and redistributed nephron filtration rate to changes in proximal tubular fractional reabsorption during acute saline infusion and aortic constriction in the ratJCI Insight, 1971
- On the Mechanism of Inhibition in Fluid Reabsorption by the Renal Proximal Tubule of the Volume-Expanded RatJCI Insight, 1971
- The relationship between peritubular capillary protein concentration and fluid reabsorption by the renal proximal tubuleJCI Insight, 1969