SYNTHESIS OF ENANTIOMERICALLY PURE AMINOPHOSPHONIC ACIDS
- 1 March 1988
- journal article
- research article
- Published by Taylor & Francis in Phosphorus and Sulfur and the Related Elements
- Vol. 36 (1-2), 73-77
- https://doi.org/10.1080/03086648808079000
Abstract
An efficient general asymmetric synthesis of α-aminophosphonic acid derivatives has been achieved by alkylation of the Schiff bases 2, prepared from (1R,2R, 5R)(+) or (1S,2S, 5S)(-) 2-hydroxy 3-pinanone 1 and α-aminomethyl phosphonic acid diethylester. Diastereoisomeric alkylated Schiff bases separated on column chromatography afforded after hydrolytic cleavage enantiomerically pure compounds.Keywords
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