Electrophysiologic Evidence for Involvement of Acetylcholine as a Neurotransmitter in the Lateral Vestibular Nucleus
- 1 November 1981
- journal article
- Published by Wiley in Otolaryngology -- Head and Neck Surgery
- Vol. 89 (6), 1025-1029
- https://doi.org/10.1177/019459988108900629
Abstract
Monosynaptic spike generation of lateral vestibular nucleus (LVN) neurons with vestibular nerve stimulation in cats was inhibited by microiontophoretic atropine and gamma-aminobutyric acid (GABA). Spontaneous firing of the LVN monosynaptic neuron was increased by iontophoretic acetylcholine and glutamate. Atropine inhibited acetylcholine-induced firing without affecting glutamate-induced firing, while GABA blocked spike generation produced by acetylcholine and glutamate. Acetylcholine probably plays a role in transmission from the vestibular nerve to the LVN monosynaptic neurons.Keywords
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