Histamine Affects Release and Biosynthesis of Opioid Peptides Primarily via H1‐Receptors in Bovine Chromaffin Cells
- 1 December 1987
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 49 (6), 1688-1696
- https://doi.org/10.1111/j.1471-4159.1987.tb02426.x
Abstract
Histamine is a potent secretagogue for opioid pentapeptides (Met- and Leu-enkephalin) in adrenal chromaffin cells in vitro. This effect is dependent on extracellular Ca2+ and is reduced by Ca2+ channel blockers such as Co2+, D 600, and nifedipine. Moreover, histamine also produced a profound compensatory increase in cellular peptide content after 48 h of exposure, most likely caused by a four- to fivefold increase in the mRNA levels coding for the proenkephalin A precursor. All the histamine-in-duced effects (acute release, changes in peptide cell content, proenkephalin A mRNA levels) are antagonized by the H1-receptor antagonist, clemastine, whereas the H2-receptor antagonists, ranitidine and cimetidine, were less effective (∼20% inhibition).Keywords
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