Vesicoureteral Reflux in the Primate IV: Does Reflux Harm the Kidney?

Abstract

Vesicoureteral reflux causes renal scarring because of intrarenal reflux. Reflux in the monkey [Macaca arctoides] was studied because of its similarity to man, especially in regard to the incidence of vesicoureteral reflux and chronic pyelonephritis. High pressure moderate grade reflux was produced and renal function followed by means of quantitative renal camera studies using 131I hippuran. There was no change in renal function from sterile reflux even when intrarenal reflux occurred. Infection was introduced, renal function decreased. Apparently, sterile moderate vesicoureteral or intrarenal reflux does not harm the kidney.