Experimental Anticholinergic Psychotomimetics: Antagonism of Yohimbine and Tacrine (THA)

Abstract

A dog behavioral-screening procedure is proposed to evaluate both the effects of Ditran and related anticholinergic psychotomimetics and blocking agents effective against this druginduced model state. The effects of atropine, Ditran and Ro 2-3308 were compared in this dog test system. Several compounds were examined to compare their antagonistic activity against these three psychotogens. THA and yohimbine both produced antagonistic activity against Ditran and Ro 2-3308, but they exhibited a different time profile of peak antagonistic activity. A hypothesis is presented which attempts to evaluate the differences in the effects of these 2 antagonists.