Predictors of ratio of placental weight to fetal weight in multiethnic community
- 18 February 1995
- Vol. 310 (6977), 436-439
- https://doi.org/10.1136/bmj.310.6977.436
Abstract
Objective: To determine whether placental ratio is influenced by maternal ethnic origin, obesity, hypertension, and haematological indices of iron deficiency anaemia. Design: Observational study. Setting: District general hospital in Birmingham. Subjects: 692 healthy nulliparous pregnant women, of whom 367 were European, 213 Asian, 99 Afro-Caribbean, and 13 of other or undocumented ethnic origin. Main outcome measures: Placental ratio and maternal body mass index, blood pressure, and haematological indices. Results: Though birth weight and placental weight were lower in Asian women than in other groups, mean placental ratio was similar in Asian (19.5% (SD 3.3%)), European (20.0% (4.0%)), and Afro-Caribbean women (20.4% (5.3%)). Gestational age at birth was the main predictor of placental ratio in the univariate analysis (r= -0.34, PConclusions: These data do not support the proposed association between poor maternal nutrition and increased placental ratio. The association between high placental ratio and adult hypertension may be confounded by genetic and environmental factors associated with maternal obesity (and possibly maternal hypertension). Key messages Poor maternal nutrition has been suggested as a determinant of placental ratio, and an association with haematological indices of iron deficiency anaemia has been described In this study of European, Asian, and Afro-Caribbean pregnant women placental ratio was increased in the offspring of obese women Placental ratio was not significantly associated with first antenatal visit haemoglobin concentrations or mean cell volume, change in mean cell volume between the first antenatal visit and the third trimester, or third trimester serum ferritin concentration These findings do not support the hypothesis that raised placental ratio is a marker for poor maternal nutritionKeywords
This publication has 11 references indexed in Scilit:
- Relation of maternal blood pressure during pregnancy to birth weight and blood pressure in children. The Hypertension in Pregnancy Offspring StudyJournal of Internal Medicine, 1994
- Urinary microalbumin excretion in early pregnancy and gestational age at delivery.BMJ, 1993
- Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?The Lancet, 1993
- Glucocorticoid exposure in utero: new model for adult hypertensionThe Lancet, 1993
- A multivariate analysis of risk factors for preeclampsia.1991
- The intrauterine origins of cardiovascular and obstructive lung disease in adult life. The Marc Daniels Lecture 1990.1991
- The classification and definition of the hypertensive disorders of pregnancyAmerican Journal of Obstetrics and Gynecology, 1988
- Effect of dietary supplements of guar gum and cellulose on intestinal cell proliferation, enzyme levels and sugar transport in the ratBritish Journal of Nutrition, 1984
- Subethnic variation in the diets of Moslem, Sikh and Hindu pregnant women at Sorrento Maternity Hospital, BirminghamBritish Journal of Nutrition, 1984
- An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overloadJournal of Clinical Pathology, 1972