Bilineal transmission of Parkinson disease on Crete suggests a complex inheritance
- 9 March 2004
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 62 (5), 815-817
- https://doi.org/10.1212/01.wnl.0000113720.71387.88
Abstract
The authors studied Parkinson disease (PD) in natives of Crete, a population sharing a common genetic and cultural background. Analysis of data from 247 index PD cases revealed a hereditary component for PD (OR 3.37; p < 0.001 for a first-degree relative of a PD patient). In 12 bilineal families (PD originating from both parental sides) identified, a high proportion (43%) of bilineal members had PD, but only 5.7% of their offspring were affected. These data suggest a recessive or an oligogenic inheritance for PD.Keywords
This publication has 9 references indexed in Scilit:
- Genetic and environmental factors in the cause of Parkinson's diseaseAnnals of Neurology, 2003
- Gene finding in genetically isolated populationsHuman Molecular Genetics, 2002
- Familial occurrence of Parkinson's disease in a community-based case-control studyParkinsonism & Related Disorders, 2001
- Familial Aggregation of Parkinson's Disease in IcelandNew England Journal of Medicine, 2000
- Familial aggregation of Parkinson’s diseaseNeurology, 1999
- Parkinson's DiseaseNew England Journal of Medicine, 1998
- Risk of Parkinson's disease among first-degree relativesNeurology, 1996
- What features improve the accuracy of clinical diagnosis in Parkinson's diseaseNeurology, 1992
- Hypothesis: Homozygosity in tourette syndromeAmerican Journal of Medical Genetics, 1989