Sodium Losing Material in Human Urine.

Abstract

Summary A substance has been obtained by chromatographic separation of extracts of urine obtained from premature infants and patients with congenital adrenal hyperplasia which when injected into intact rats produces an increase in urinary sodium excretion. The material is found more plentifully after ACTH administration to the patient but it has not been proven to be a secretory product of the adrenal cortex. It has minimal or no effect upon potassium excretion. It does not cause its effect by increasing glomerular filtration, at least as evidenced by creatinine excretion.