Penicillin as Epileptogenic Agent: Its Effect on an Isolated Neuron
- 27 February 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 167 (3922), 1257-1260
- https://doi.org/10.1126/science.167.3922.1257
Abstract
Penicillin induces partial depolarization and increased excitability of the neuronal membrane of crayfish stretch receptor. Such effects suggest that the epileptic focus created by the topical application of penicillin to the mammalian cerebral cortex may result from the lowering of the threshold for impluse initiation by excitatory synaptic action within the neuron population.Keywords
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