Spontaneous resolution of cervical warty atypia: the relevance of clinical and nuclear DNA features: a prospective study

Abstract

A selected group of 51 patients with histological features of cervical warty atypia was observed for 1 yr. Initial features were compared with a cohort of 50 patients with CIN [cervical intraepithelial neoplasia]. Patients (24) showed resolution of the warty atypia, in 19 it remained unchanged, and in 8 patients CIN or microinvasive disease was present on repeat biopsy. The DNA patterns obtained by tissue imprint of the initial biopsies and subsequent integrated densitometry, using a Vickers M85 scanning densitometer, showed that warty atypias could be objectively distinguished from CIN, but that the method could not predict the group of warty atypias that would resolve. There was no clinical feature or group of features which allowed a means of predicting the outcome of such lesions.