Estrogen Induction of Hepatocellular Carcinomas in Armenian Hamsters

Abstract

Liver tumors were found in most Armenian hamsters (Cricetulus migratorius) injected with on 15–mg pellet of diethylstilbestrol. The tumors were detectable as early as 1.5 mo after diethylstilbestrol administration and were usually present as multiple nodules that progressively increased in size. Histologically, the multicentric neoplasms were all hepatocellular carcinomas of varied degrees of differentiation and frequently (42.8%) contained Mallory bodies; preneoplastic lesions were not observed. This hepatocellular carcinoma hamster model is unique because estrogen alone without any other known mutagen is responsible for induction of hepatocellular carcinoma.(HEPATOLOGY 1990; 11:570:577.)