Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells
- 1 June 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 333 (6173), 529-533
- https://doi.org/10.1038/333529a0
Abstract
A class I histocompatibility gene, H-2Kb, linked to the rat insulin promoter, is overexpressed in the pancreatic beta cells of transgenic mice. The mice, whether syngeneic or allogeneic to the transgene, develop insulin dependent diabetes without detectable T cell infiltration, suggesting a direct, non-immune role for the transgenic class I molecules in the disease process.Keywords
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