Molecular Recogniton of Polysaccharide-Coated Liposomes. Importance of Sialic Acid Moiety on Liposomal Surface
- 5 October 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 17 (10), 1781-1784
- https://doi.org/10.1246/cl.1988.1781
Abstract
Conjugation of sialic acid to cholesterol-substituted polysaccharides has been carried out. Liposomes, which are coated with sialic acid-modified polysaccharide, were significantly aggregated by sialic acid-specific lectin, and inhibition of phagocytosis of the liposomes by phagocytic cells was observed. Appropriate treatment of the liposomes with a neuraminidase made the efficient removal of sialic acid from the polysaccharide on the liposomal surface.Keywords
This publication has 6 references indexed in Scilit:
- A newly developed immunoliposome — an egg phosphatidylcholine liposome coated with pullulan bearing both a cholesterol moiety and an IgMs fragmentBiochimica et Biophysica Acta (BBA) - Biomembranes, 1987
- Effect of surface modification of liposomes with sialoglycopeptide on their clearance from the circulation.CHEMICAL & PHARMACEUTICAL BULLETIN, 1986
- Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injectionBiochimica et Biophysica Acta (BBA) - General Subjects, 1985
- Induction of suppressor T cells by neuraminic acid derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN, 1982
- A study of phospholipid interactions between high-density lipoproteins and small unilamellar vesiclesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1981
- Tissue distribution of EDTA encapsulated within liposomes containing glycolipids or brain phospholipidsBiochimica et Biophysica Acta (BBA) - General Subjects, 1978