DO PYRIMIDINE DIMER YIELDS CORRELATE WITH ERYTHEMA INDUCTION IN HUMAN SKIN IRRADIATED in situ WITH ULTRAVIOLET LIGHT (275–365 nm)?
- 1 April 1991
- journal article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 53 (4), 559-563
- https://doi.org/10.1111/j.1751-1097.1991.tb03671.x
Abstract
Ultraviolet radiation produces erythema in human skin, and damages the DNA of living cells in skin. Previous work showed that broad-band UV-B (290-320 nm) radiation produced higher levels of cyclobutyl pyrimidine dimers in DNA of individuals with high UV-B sensitivity (low minimal erythema dose) than in subjects of low UV-B sensitivity [Freeman et al. (1986) J. Invest. Dermatol., 86, 34-36]. We examined the relationship between erythema induction and dimer yields in DNA of human skin irradiated in situ with narrow band radiation spanning the wavelength range 275-365 nm. We find that, in general, higher dimer yields are produced per incident photon in volunteers with higher susceptibility to erythema induced by radiation of the same wavelength.Keywords
This publication has 26 references indexed in Scilit:
- RESEARCH NOTE.Photochemistry and Photobiology, 1990
- Cyclobuta-Dithymidine Induction by Solar-Simulating UV Radiation in Human Skin: II. Individual Responses.Journal of Investigative Dermatology, 1989
- SINGLET OXYGEN INVOLVEMENT IN THE INACTIVATION OF CULTURED HUMAN FIBROBLASTS BY UVA (334 nm, 365 nm) AND NEAR‐VISIBLE (405 nm) RADIATIONSPhotochemistry and Photobiology, 1989
- Higher Pyrimidine Dimer Yields in Skin of Normal Humans with Higher UVB SensitivityJournal of Investigative Dermatology, 1986
- Photoreactivation in Bacteria and in SkinJournal of Investigative Dermatology, 1981
- ACTION SPECTRA FOR KILLING NON‐DIVIDING NORMAL HUMAN AND XERODERMA PIGMENTOSUM CELLSPhotochemistry and Photobiology, 1980
- AN ACTION SPECTRUM FOR CELL KILLING AND PYRIMIDINE DIMER FORMATION IN CHINESE HAMSTER V‐79 CELLSPhotochemistry and Photobiology, 1979
- Photoreactivating enzyme from human leukocytesNature, 1974
- The production of mucosal ulceration in the rabbit gut by intra‐arterial injection of microspheresThe Journal of Pathology, 1970
- Cyclobutane-Type Pyrimidine Dimers in PolynucleotidesScience, 1966