DDAVP in the Treatment of Central Diabetes Insipidus
- 4 March 1976
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 294 (10), 507-511
- https://doi.org/10.1056/nejm197603042941001
Abstract
DDAVP, 1-desamino-8-d-arginine-vasopressin, is a synthetic analogue of vasopressin with increased antidiuretic activity and decreased pressor activity. Whereas the antidiuretic-to-pressor ratio of arginine vasopressin is 1, the antidiuretic-to-pressor ratio of DDAVP is 4000. When administered as an intranasal spray, 5 to 20 μg of DDAVP produced eight to 20 hours of antidiuresis in patients with complete central diabetes insipidus. The minimum recommended therapeutic dose resulted in a maximum antidiuresis in most patients. No side effects of the drug were noted in clinical trials. DDAVP thus gives promise of becoming the standard treatment of severe central diabetes insipidus. (N Engl J Med 294:507–511, 1976)This publication has 31 references indexed in Scilit:
- DDAVP in Treatment of Vasopressin-Sensitive Diabetes InsipidusBMJ, 1974
- A vasopressin analogue in treatment of diabetes insipidusArchives of Disease in Childhood, 1974
- Postnatal Development of Renal Concentration Capacity as Estimated by DDAVP-Test in Normal and Asphyxiated NeonatesNeonatology, 1974
- TREATMENT OF DIABETES INSIPIDUS IN CHILDREN WITH DDAVP, A SYNTHETIC ANALOGUE OF VASOPRESSINActa Paediatrica, 1973
- Clofibrate-Induced AntidiuresisJournal of Clinical Investigation, 1973
- Mechanism of Inactivation of Vasopressin and Oxytocin by the Isolated Perfused Rat Kidney*Endocrinology, 1973
- Management of diabetes insipidus in pregnancy.BMJ, 1972
- EFFECTS OF DDAVP, A SYNTHETIC ANALOGUE OF VASOPRESSIN, IN PATIENTS WITH CRANIAL DIABETES INSIPIDUSActa Medica Scandinavica, 1972
- CHLORPROPAMIDE IN DIABETES INSIPIDUSThe Lancet, 1969
- EFFECT OF A SYNTHETIC ANALOGUE OF VASOPRESSIN IN ANIMALS AND IN PATIENTS WITH DIABETES INSIPIDUSThe Lancet, 1968