A Syndrome of Primary Hypothyroidism, Amenorrhea and Galactorrhea

Abstract

We have reported a patient with primary hypothyroidism, galactorrhea and amenorrhea and have found 3 similar patients in a review of the literature. All 4 occurred in the postpartum state, and none exhibited evidence of a pituitary tumor. These cases appear to represent a distinct clinical entity. Although certain features suggest the syndrome of “hormonal overlap,” the authors believe the abnormality is inhibition by the hypothyroid state of the hypothalamic center controlling release of prolactin and luteinizing hormone. Supporting evidence for this is reviewed. This syndrome must be distinguished from the Chiari-Frommel syndrome since it is amenable to therapy with thyroid hormone.