Simulation In Vitro of Pulsatile Vascular Hemodynamics Using a CAD/CAM‐Designed Cam Disc and Roller Follower

Abstract

An in vitro perfusion circuit is described that is capable of simulating pulsatile peripheral vascular hemodynamics. A novel feature of its design is the incorporation of a computer-aided design and manufacture disc cam and foller follower for delivery of pulsatile hemodynamics. To date .apprx. 75 canine carotids have been perfused for periods of 2-24 h. The delivery of quantifiable hemodynamics in vitro via the rotation of a cam and roller follower has been found to be highly reliable on a cycle-to-cycle basis.