Influence of vitamin B12 on brain methionine adenosyltransferase activity in senile dementia of the Alzheimer's type
- 1 July 1996
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 103 (7), 861-872
- https://doi.org/10.1007/bf01273364
Abstract
Summary The influence of vitamin B12 on the activity of methionine adenosyltransferase (MAT) in postmortem brains of patients with senile dementia of the Alzheimer's type (SDAT) was investigated. In samples of cortex gyrus frontalis from SDAT patients with normal and low levels of serum B12, MAT Vmax was significantly increased by 25% and 19%, respectively. MAT Vmax from a SDAT group chronically treated with B12 was similar to controls. In contrast to cortex gyrus frontalis, no significant alterations were seen in MAT activity in nucleus caudatus. This study provides evidence that SDAT is associated with significant alterations in transmethylation mechanisms in specific regions of the brain. The relationship between blood levels of B12 and the actual status of this vitamin in the brain influencing the rates of synthesis of both methionine and SAM may, however, be far more complex and cannot be directly clarified on the basis of the present human brain results.This publication has 52 references indexed in Scilit:
- Methionine Synthase and Methionine Adenosyltransferase Activities in Rat Brain after Ethanol TreatmentBasic & Clinical Pharmacology & Toxicology, 1993
- Brain Protein Synthesis in the Conscious Rat Using L-[35S]Methionine: Relationship of Methionine Specific Activity Between Plasma and Precursor Compartment and Evaluation of Methionine Metabolic PathwaysJournal of Neurochemistry, 1992
- Slowed synthesis of DNA and methionine is a pathogenetic mechanism common to dementia in down's syndrome, AIDS and Alzheimer's disease?Medical Hypotheses, 1992
- Serum and Cerebrospinal Fluid Vitamin B12 Levels in Demented Patients with CH3—B12 Treatment—Preliminary Study—Psychiatry and Clinical Neurosciences, 1988
- The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissueJournal of Neural Transmission, 1985
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984
- Methionine Adenosyltransferase ( S ‐Adenosylmethionine Synthetase) and S ‐Adenosylmethionine DecarboxylasePublished by Wiley ,1984
- VARIOUS DEGREES OF DEMENTIA IN A SELECTED GROUP OF GASTRECTOMIZED PATIENTS WITH LOW SERUM B12Acta Neurologica Scandinavica, 1977
- TRANS‐SULPHURATION IN PRIMATE BRAIN: REGIONAL DISTRIBUTION OF METHIONINE‐ACTIVATING ENZYME IN THE BRAIN OF THE RHESUS MONKEY AT VARIOUS STAGES OF DEVELOPMENTJournal of Neurochemistry, 1970