EFFECTS OF INFLAMMATION ON PROTEINS AND ENZYMES IN RAT PLASMA

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Abstract
The effects of anaphylactoid inflammation in rats on the limb volume, hematocrit, and plasma proteins, and on the activities of plasmin, antiplasmin, and esterase of the plasma were studied. The hyperemia and edema of the limbs and other extremities which occurred following the injection of dextran were found to be accompanied by a transient hemoconcentration and a prolonged depression in the concentration of plasma proteins (both albumin and globulin fractions). The specific activity of plasma esterase was increased and that of antiplasmin was decreased during inflammation compared with control animals. No consistent or significant change was observed in the specific activity of plasmin.