Comparison and Standardization of Measurement of Anti-Acetylcholine Receptor Antibody between Laboratories
- 1 January 1988
- journal article
- Published by Taylor & Francis in Autoimmunity
- Vol. 1 (1), 59-66
- https://doi.org/10.3109/08916938808997177
Abstract
The presence of autoantibodies to the acetylcholine receptor (anti-AChR) is useful in the diagnosis of myasthenia gravis, and their titre correlates with severity of the disease. Standardization of their measurement is therefore clinically important. Six laboratories world-wide were asked to determine anti-AChR under local conditions in coded samples and to repeat the measurement on the same samples recoded. There was a high degree of consensus over rank order of the samples but a wide systematic variation in the titres obtained. Standardization of units is an important next step in improving the comparability of anti-AChR data between laboratories.Keywords
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