Assessment of the Antihypercholesterolemic Drug, Probucol, in Benign Prostatic Hyperplasia

Abstract

Seventy patients were administered either Probucol, an anti-cholesterol agent, or a placebo in a double blind manner for a period of 1 yr in an effect to assess the effectiveness of this agent in treating benign prostatic hyperplasia. Sensation of incomplete voiding and peak and mean voiding flow rates showed a trend which indicated a therapeutic effect; however, this effect was comparable for both placebo and the drug group. This is interpreted as indicating the effectiveness of standard urologic therapy, and double blind trials are therefore needed in assessing different agents for the medical management of benign prostatic hyperplasia.