EVIDENCE FOR LINKAGE DISEQUILIBRIUM MAINTAINED BY SELECTION IN TWO NATURAL POPULATIONS OF DROSOPHILA SUBOBSCURA
Open Access
- 1 April 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 73 (4), 659-674
- https://doi.org/10.1093/genetics/73.4.659
Abstract
One island and one mainland population of Drosophila subobscura were found polymorphic at the XDH (xanthine dehydrogenase) and the A0 (aldehyde oxidase) loci. It was observed that one allele at the XDH locus, which has a low frequency in both populations, is nonrandomly associated with the alleles at the A0 locus. Two lines of evidence support the thesis that this linkage disequilibrium is due to epistasis rather than random drift: (I)D or r, measures of the disequilibrium, have the same sign and magnitude in both populations. (2) The linkage disequilibrium is not due to inversions. Inversions segregating on the chromosome carrying XDH and A0 have been separated into two classes, between which exchange of alleles at the two loci is suppressed. Linkage disequilibrium for XDH and A0 was observed within each class. In the absence of any exchange of alleles, these disequilibria must have arisen and been maintained independently. The suggestion is made that the epistatic disequilibrium results from the close structural and physiological relationship which exists between the tn-o enzymes.Keywords
This publication has 9 references indexed in Scilit:
- Linkage Disequilibrium in a Local Population of Drosophila melanogasterProceedings of the National Academy of Sciences, 1971
- Transient Linkage Disequilibrium in DrosophilaNature, 1971
- A profile of Drosophila species' enzymes assayed by electrophoresis. I. Number of alleles, heterozygosities, and linkage disequilibrium in glucose-metabolizing systems and some other enzymesBiochemical Genetics, 1970
- A COMPUTER MODEL ALLOWING MAINTENANCE OF LARGE AMOUNTS OF GENETIC VARIABILITY IN MENDELIAN POPULATIONS. I. ASSUMPTIONS AND RESULTS FOR LARGE POPULATIONSGenetics, 1970
- A molecular approach to the study of genic heterozygosity in natural populations. 3. Direct evidence of coadaptation in gene arrangements of Drosophila.Proceedings of the National Academy of Sciences, 1968
- A MOLECULAR APPROACH TO THE STUDY OF GENIC HETEROZYGOSITY IN NATURAL POPULATIONS. II. AMOUNT OF VARIATION AND DEGREE OF HETEROZYGOSITY IN NATURAL POPULATIONS OF DROSOPHILA PSEUDOOBSCURAGenetics, 1966
- A MOLECULAR APPROACH TO THE STUDY OF GENIC HETEROZYGOSITY IN NATURAL POPULATIONS. I. THE NUMBER OF ALLELES AT DIFFERENT LOCI IN DROSOPHILA PSEUDOOBSCURAGenetics, 1966
- An analysis of polymorphisms among isozyme loci in dark and light Drosophila ananassae strains from American and Western Samoa.Proceedings of the National Academy of Sciences, 1966
- Basic Research—Description versus DefinitionScience, 1959