Polymorphic plasma postalbumins of some domestic animals (pig PO2, horse Xk and dog Pa proteins) identified as homologous to human plasma α1B-glycoprotein

Abstract

Pig, horse and dog plasma proteins, separated by horizontal polyacrylamide gel electrophoresis (pH 9.0) and electrophoretically transferred to nitrocellulose membranes, were tested for cross-reaction with antiserum to human plasma .alpha.1-B-glycoprotein (.alpha.1B). The results showed that one previously reported polymorphic plasma postalbumin in each of these species (pig PO2, horse Xk and dog Pa protein) was homologous to human plasma .alpha.1B. In the light of the previously known genetic linkages in these species, this implied: (1) .alpha.1B gene is close linked to Phi, Pgd and Hal (halothane sensitivity locus) loci in pigs; and (2) .alpha.1B gene is linked to ME1 and Phi locus in horses. This suggested that the .alpha.1B gene may also be found to be closely linked to gene(s) controlling susceptibility to malignant hyperthermia in humans and other mammals.