Effect of Continuous Glucose Infusion on the Glucose-6-Phosphatase Activity of the Liver in Rats

Abstract

ASHMORE, Hastings and Nesbett¹ reported that the glucose-6-phosphatase activity of the liver is elevated in the diabetic animal and that the administration of insulin to diabetic rats causes the elevated level of glucose-6-phosphatase activity in the liver to return to normal. Langdon and Weakley² found that the injection of insulin into alloxan-diabetic rats twelve hours before death resulted in a return of liver glucose-6-phosphatase activity to normal levels. Ashmore et al.³ reported that the injection of insulin into normal rats caused a decrease in the glucose-6-phosphatase of the liver. Harper⁴ concluded from his study of the effect of hormonal treatment . . .