Distribution in Blood and Excretion of Znc65 in Man.

Abstract

Following intravenous infusion of 50 to 100 [mu]c of Zn65 chloride to man, the plasma curve shows a continuous fall in concentration, while the red cell (RBC) concentration curve increases to the 11th day and then falls off gradually. The whole blood concentration curve resembles the plasma curve in the first few hours and the RBC curve thereafter. As shown by dialysis experiments, the isotope quickly becomes protein bound in plasma as well as in RBC''s and remains so for many days. Urinary excretion of Zn65 is independent of urine volume and proceeds at a fairly constant rate after equilibration in plasma. It is excreted as a non-protein compound. Fecal excretion demonstrates great fluctuations and is apparently enhanced by diarrheas.