Cimetidine and Salbutamol Combined Inhibition of Gastric Acid Secretion in the Dog

Abstract

The effects of salbutamol and cimetidine, alone and in combination, on pentagastrin-stimulated gastric secretion were studied in conscious dogs with gastric fistulae. Salbutamol 24 nmol/kg.cntdot.h alone and cimetidine 4 .mu.mol/kg.cntdot.h alone inhibited acid by up to 69%, cimetidine 8 .mu.mol/kg.cntdot.h produced up to 87% inhibition and the combination of cimetidine 4 .mu.mol/kg.cntdot.h and salbutamol 24 nmol/kg.cntdot.h almost totally inhibited acid (up to 99%). The pharmacokinetics of these inhibitions were studied and salbutamol and/or cimetidine caused a complex uncompetitive inhibition of pentagastrin-stimulated acid. The inhibitory combination of the 2 drugs was additive.