Peripheral Metabolism of Thyroid Hormones in Guinea Pigs Immunized Against Bovine Thyroglobulin.
- 1 June 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 110 (2), 277-279
- https://doi.org/10.3181/00379727-110-27491
Abstract
Summary The time required for the disappearance from the blood of one-half the radioactivity (ty1/2) of thyroxine (T4131) and triiodothyronine (T3131) has been studied in normal, adjuvant treated and thyroglobulin-adjuvant immunized guinea pigs. The antibody titer in immunized animals has been estimated by the tanned red cell hemagglutination technic. The titer at 8-9 weeks was greater than at 4-5 weeks after immunization. The t1/2 of T4131 and of T3131 of experimental animals was not significantly different from that of untreated and adjuvant treated controls at 5 weeks after immunization. However, at 12 weeks after immunization the t1/2 of both radioactive hormones was markedly increased; the increase was by 201% in the case of T4131 and by 86.4% in the case of T3131. There was a gross inverse relationship between the t1/2 of these radioactive hormones and the magnitude of the antibody titer. The implications of this inverse relationship have been briefly discussed.Keywords
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