Polyhalogenoheterocyclic compounds. Part XXVI. Nucleophilic substitution in trifluoropyrazines

Abstract

The orientation of substitution in trifluoropyrazines C₄N₂F₃X (X = H, Cl, Br, OMe, or NMe₂) by methoxide and dimethylamine is described. Further attack para to H, Cl, or Br and ortho to OMe occurs; attack ortho to Me₂N is observed when steric factors permit. The synthesis of perfluorobipyrazin-2-yl is reported.