Correlation of virus polypeptide structure with attenuation of poliovirus type 1
- 31 August 1977
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 23 (3), 811-815
- https://doi.org/10.1128/jvi.23.3.811-815.1977
Abstract
Several avirulent samples of poliovirus type 1 derived in the process attenuating the neurovirulent Mahoney strain show an altered virus capsid polypeptide, VP-1, on polyacrylamide gel electrophoresis of sodium dodecyl sulfate-disrupted virions. [This study has relevance in assaying decrease in neurovirulence of poliovirus for vaccine production.].This publication has 6 references indexed in Scilit:
- Three structural polypeptides coded for by minite virus of mice, a parvovirusJournal of Virology, 1976
- Cleavage site alterations in poliovirus-specific precursor proteinsVirology, 1976
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970
- Isolation of a Non-Neurotropic Variant of Type I Poliomyelitis VirusExperimental Biology and Medicine, 1954