REPRESSION OF ALKALINE PHOSPHATASE IN HUMAN CELL CULTURES BY CYSTINE AND CYSTEINE
- 1 April 1963
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 49 (4), 504-510
- https://doi.org/10.1073/pnas.49.4.504
Abstract
Alkaline phosphatase of certain established human cell cultures is repressed by cyst(e)ine, a constituent of the usual growth media. Forty hours are required for substantial cyst(e)ine-mediated repression of alkaline phosphatase. The observations described suggest that repression is caused by interference with enzyme synthesis or activation rather than sulfhydryl inhibition of alkaline phosphatase activity.Keywords
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