Key role for spinal dorsal horn microglial kinin B1receptor in early diabetic pain neuropathy
Open Access
- 29 June 2010
- journal article
- Published by Springer Nature in Journal of Neuroinflammation
- Vol. 7 (1), 36
- https://doi.org/10.1186/1742-2094-7-36
Abstract
The pro-nociceptive kinin B1 receptor (B1R) is upregulated on sensory C-fibres, astrocytes and microglia in the spinal cord of streptozotocin (STZ)-diabetic rat. This study aims at defining the role of microglial kinin B1R in diabetic pain neuropathy.Keywords
This publication has 65 references indexed in Scilit:
- Trafficking of neurokinin-1 receptors in serotonin neurons is controlled by substance P within the rat dorsal raphe nucleusEuropean Journal of Neuroscience, 2009
- Cellular localization of kinin B1 receptor in the spinal cord of streptozotocin-diabetic rats with a fluorescent [Nα-Bodipy]-des-Arg9-bradykininJournal of Neuroinflammation, 2009
- Activation of p38 Mitogen-activated Protein Kinase in Spinal Microglia Contributes to Incision-induced Mechanical AllodyniaAnesthesiology, 2009
- NADPH oxidase as a therapeutic target in Alzheimer's diseaseBMC Neuroscience, 2008
- Interferon-γ Is a Critical Modulator of CB2Cannabinoid Receptor Signaling during Neuropathic PainJournal of Neuroscience, 2008
- Blockade of microglial glutamate release protects against ischemic brain injuryExperimental Neurology, 2008
- Protective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathyLife Sciences, 2008
- The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistanceBritish Journal of Pharmacology, 2007
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001
- NMDA receptor antagonist blocks the facilitation of the tail flick reflex in the rat induced by intrathecal administration of substance P and by noxious cutaneous stimulationNeuroscience Letters, 1991