β-Galactosidase: Inactivation of Its Messenger RNA by Ultraviolet Irradiation
- 6 November 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 146 (3645), 791-794
- https://doi.org/10.1126/science.146.3645.791
Abstract
A brief exposure of Escherichia coli cells to an indutcer for β- galactosidase results in the production of a messenger RNA which subsequently expresses itself as β-galactosidase. Ultraviolet irradiation of cells after exposure to the inducer results in a decrease in the amount of β-galactosidase formed. The messenger RNA formed during the brief exposure to inducer is evidently inactivated by the ultraviolet radiation. The decay of messenger RNA activity in irradiated cells has the same kinetics as that observed in unirradiated cells.Keywords
This publication has 14 references indexed in Scilit:
- INACTIVATTON OF S‐RNA BY ULTRAVIOLET RADIATIONSPhotochemistry and Photobiology, 1964
- The roles of inducer and catabolite repressor in the synthesis of β-galactosidase by Escherichia coliJournal of Molecular Biology, 1964
- Thymine Dimers and Inhibition of DNA Synthesis by Ultraviolet Irradiation of CellsScience, 1963
- Failure of ultraviolet-irradiated Escherichia coli to produce a cross-reacting proteinBiochimica et Biophysica Acta, 1962
- Quantitative Radioautographic Studies on Exponentially Growing Cultures of Escherichia coliBiophysical Journal, 1961
- The initial kinetics of enzyme inductionBiochimica et Biophysica Acta, 1961
- Effect of monochromatic ultraviolet light on macromolecular synthesis in Escherichia coliBiochimica et Biophysica Acta, 1960
- Inactivation of enzyme formation by ultraviolet lightBiochimica et Biophysica Acta, 1960
- Studies on the induction of β-galactosidase in a cryptic strain of Escherichia coliBiochimica et Biophysica Acta, 1959
- Photoreactivation of galactozymase formation in yeastJournal of Cellular and Comparative Physiology, 1950