Effects of prostaglandin E 1 in experimental autoimmune myasthenia gravis
- 31 March 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 32 (4), 410
- https://doi.org/10.1212/wnl.32.4.410
Abstract
The effects of prostaglandin E1 (PGE1), a potent inhibitor of lymphocyte functions, were studied in rats immunized with acetylcholine receptor (AChR) to induce experimental autoimmune myasthenia gravis (EAMG). Daily injections of PGE1, 400 μg per day, prevented the development of acute EAMG, which is attributed to antibody-dependent, complement-mediated cytolysis. This was associated with suppression of delayed-type cutaneous hypersensitivity response to AChR. PGE, did not prevent the subsequent onset of chronic EAMG, which reflects accelerated degradation of AChR by antibody and complement-mediated cell lysis in the postsynaptic membrane.This publication has 15 references indexed in Scilit:
- Myasthenia and Prostaglandin E_1Annals of Internal Medicine, 1979
- Effect of myasthenic patients' immunoglobulin on acetylcholine receptor turnover: selectivity of degradation process.Proceedings of the National Academy of Sciences, 1978
- Role of complement in the pathogenesis of experimental autoimmune myasthenia gravis.The Journal of Experimental Medicine, 1978
- Ultrastructural Localization of Immune Complexes (IGG and C3) at the End-Plate in Experimental Autoimmune Myasthenia GravisJournal of Neuropathology and Experimental Neurology, 1978
- Modulation of acetylcholine receptor by antibody against the receptorProceedings of the National Academy of Sciences, 1977
- Quinacrine is a prostaglandin antagonistBiochemical and Biophysical Research Communications, 1977
- Accelerated degradation of acetylcholine receptor from cultured rat myotubes with myasthenia gravis sera and globulins.Proceedings of the National Academy of Sciences, 1977
- Prostaglandins and the immune responseLife Sciences, 1977
- Prostaglandin E1 treatment of NZB/NZW miceArthritis & Rheumatism, 1977
- Pathological mechanisms in experimental autoimmune myasthenia gravis. I. Immunogenicity of syngeneic muscle acetylcholine receptor and quantitative extraction of receptor and antibody-receptor complexes from muscles of rats with experimental automimmune myasthenia gravis.The Journal of Experimental Medicine, 1976