Surface activation of blood coagulation, fibrinolysis and kinin formation

Abstract
The activation of plasma prekallikrein by [human] single-chain factor XII has been studied in the presence of high MW kininogen and kaolin. Factor XII can apparently initiate blood coagulation, fibrinolysis or kinin generation in the presence of kaolin and does so by converting prekallikrein to kallikrein. An enzyme cascade is then generated leading to the formation of fibrin, plasmin or bradykinin in 3 closely-related physiological events.