Surface activation of blood coagulation, fibrinolysis and kinin formation
- 1 July 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 286 (5772), 456-460
- https://doi.org/10.1038/286456a0
Abstract
The activation of plasma prekallikrein by [human] single-chain factor XII has been studied in the presence of high MW kininogen and kaolin. Factor XII can apparently initiate blood coagulation, fibrinolysis or kinin generation in the presence of kaolin and does so by converting prekallikrein to kallikrein. An enzyme cascade is then generated leading to the formation of fibrin, plasmin or bradykinin in 3 closely-related physiological events.This publication has 37 references indexed in Scilit:
- Mechanism of activation of bovine factor XI by factor XII and factor XIIaBiochemistry, 1980
- Isolation and characterization of bovine plasma prekallikrein (Fletcher factor)Biochemistry, 1979
- The autoactivation of rabbit hageman factorThe Journal of Experimental Medicine, 1979
- Characterization of bovine factor XIIa (activated Hageman factor)Biochemistry, 1977
- Purification of High Molecular Weight Kininogen and the Role of This Agent in Blood CoagulationJCI Insight, 1977
- Isolation and characterization of bovine factor XI (plasma thromboplastin antecedent)Biochemistry, 1977
- PREKALLIKREIN DEFICIENCY IN MANThe Journal of Experimental Medicine, 1973
- A PREALBUMIN ACTIVATOR OF PREKALLIKREINThe Journal of Experimental Medicine, 1971
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970
- Partial purification of bovine plasma kallikreinogen, its activation by the Hageman factorBiochemical and Biophysical Research Communications, 1968