Enhancement of Detrusor Reflex Activity by Naloxone in Patients With Chronic Neurogenic Bladder Dysfunction. Preliminary Report
- 1 October 1981
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 126 (4), 500-502
- https://doi.org/10.1016/s0022-5347(17)54596-6
Abstract
An i.v. injection of 0.4 mg naloxone enhanced detrusor reflex activity in 5 patients with chronic neurogenic bladder dysfunction caused by incomplete suprasacral spinal lesions. The intravesical volume at which detrusor reflex occurred showed a decrease from 498.2 to 346.2 ml. The naloxone-induced effect was short-lived, being absent 1 h after the injection. In the same dosage naloxone did not induce detrusor reflex in 2 patients with areflexic bladder caused by complete suprasacral spinal lesions.This publication has 8 references indexed in Scilit:
- Paradoxical effect of naloxone on nitrous oxide analgesia in manEuropean Journal of Pharmacology, 1980
- On the specificity of naloxone as an opiate antagonistLife Sciences, 1979
- Potentiation by naloxone of reflex activity in the isolated spinal cord of XenopusEuropean Journal of Pharmacology, 1979
- From intermittent catheterisation to catheter freedom via urodynamics: a tribute to Sir Ludwig GuttmannSpinal Cord, 1979
- Enkephalin pentapeptides — A review of current evidence for a physiological role in vertebrate neurotransmissionLife Sciences, 1977
- Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medullaBrain Research, 1977
- THE OPIATE RECEPTOR AND OPIOID PEPTIDESJournal of Neurochemistry, 1977
- Enhancement of reflexes by naloxone in spinal catsNeuropharmacology, 1976