Clinical pharmacokinetic study of 5-FU in continuous 5-day infusions for head and neck cancer
- 1 January 1986
- journal article
- research article
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 16 (1), 64-66
- https://doi.org/10.1007/bf00255288
Abstract
Summary Twenty-nine previously untreated patients with head and neck carcinoma received a total of 63 cycles of an initial chemotherapy protocol combining cis-platinum (100 mg/m2 on day 1) and continuous 5-day infusion of 5-FU (1000 mg/m2/24 h) from day 2 to day 6. This protocol was repeated on day 16 and day 31. Two daily blood samples obtained from all patients every day during 5-FU administration were analyzed by HPLC to determine the 5-FU concentrations. In the majority of cases a constant elevation was observed in total 5-FU cycle exposure (CxT) from cycle to cycle. A close relationship was demonstrated between elevated 5-FU CxT values (over 30 000 ng h ml-1) and the frequency of cycles in which signs of toxicity (myelosuppression, mucositis, diarrhea) were observed. By contrast, no obvious association was noted between response to treatment and systemic 5-FU exposure.Keywords
This publication has 13 references indexed in Scilit:
- 5-FLUOROURACIL INCORPORATION INTO DNA OF CF-1 MOUSE BONE-MARROW CELLS AS A POSSIBLE MECHANISM OF TOXICITY1984
- Cisplatin-induced changes in bleomycin elimination.1983
- [Chemotherapy of extensive digestive cancers with 5-fluorouracil: relation between the clinical response and plasma clearance of the drug].1983
- Clinical Pharmacokinetics of Commonly Used Anticancer DrugsClinical Pharmacokinetics, 1983
- Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.1982
- CLINICAL-TRIAL OF CISPLATIN AND 5-FU INFUSION AS INITIAL TREATMENT FOR ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK1982
- The pharmacology of the fluoropyrimidines.1981
- PHARMACOKINETICS OF 5-FLUOROURACIL ADMINISTERED ORALLY, BY RAPID INTRAVENOUS AND BY SLOW INFUSION1980
- Clinical Relevance of PharmacokineticsClinical Pharmacokinetics, 1980
- Comparison of liquid- and gas-liquid chromatographic assays of 5-fluorouracil in plasma.Clinical Chemistry, 1979