Hematopoietic Stem Cells

Abstract

(Third of Three Parts)Diseases of Hemopoietic Stem CellsNeoplastic Transformation of Pluripotent Stem Cells (CFU-S)A number of hematologic disorders appear to represent neoplastic transformations of human pluripotent stem cells or stem cells common to pluripotent stem cells and the lymphoid stem cells. Chronic myelogenous leukemia (CML) has been the prototype stem-cell disease. The Philadelphia chromosome, an abnormality specific for CML, was found to be present in erythroid, granulocytic, and megakaryocytic cell lines, indicating that the disease was primarily at the pluripotent stem-cell level.^{7, 209} Further evidence of the clonal origin of human tumors has been derived from study of . . .