Localized Epileptiform Activity Induced by Murine CRF in Rats
- 1 August 1988
- Vol. 29 (4), 369-373
- https://doi.org/10.1111/j.1528-1157.1988.tb03733.x
Abstract
Murine corticotropin releasing factor (rCRF), injected intracerebroventricularly into rats at a dose of 10 .mu.g produced increased motor activity, grooming, and recurrent episodes of epileptic activity localized in the hippocampal leads. Such activity persisted for .apprx. 5 h and was characterized by recurrent trains of biphasic spikes never associated with behavioral signs of epilepsy. The intraperitoneal administration of carbamazepine (15 and 30 mg/kg) reduced the epileptic activity for .apprx. 90 and 120 min, respectively, whereas that of naloxone (8 mg/kg) was ineffective. The results suggest that rCRF-induced spiking activity might be a model of temporal lobe epilepsy.This publication has 17 references indexed in Scilit:
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