Chlorpromazine-Type Cholangitis

Abstract

SINCE the first case of cholangiolitic hepatitis and jaundice after the administration of chlorpromazine was reported by Zatuchni and Miller,¹ numerous papers dealing with various aspects of this problem have appeared in the literature. Recent authors^{2 3 4} have considered the mechanism of production of this phenomenon to lie in hepatic sensitization to the drug, rather than any of its specific pharmacologic properties. A similar type of cholangitis was reported by Hanger and Gutman⁵ in 1940 in 12 patients who had been on arsphenamine therapy. Many other compounds have been associated with the appearance of this type of obstructive jaundice, among them . . .