BEPITOPE: predicting the location of continuous epitopes and patterns in proteins
- 24 January 2003
- journal article
- research article
- Published by Wiley in Journal of Molecular Recognition
- Vol. 16 (1), 20-22
- https://doi.org/10.1002/jmr.602
Abstract
In growing need of obtaining highly specific monoclonal antibodies against novel proteins, we developed new functions implemented in the program BEPITOPE to predict continuous protein epitopes. This program not only can compute, combine, display and print prediction profiles, but also provides a list of suggested linear peptides to be synthesized. Novel facilities incorporated in BEPITOPE include the treatment of a whole genome, the search for a user-defined pattern, and the combination of prediction to pattern profiles. This latter approach is useful to remove unwanted predictions such as those including glycosylation sites. Copyright © 2003 John Wiley & Sons, Ltd.Keywords
This publication has 14 references indexed in Scilit:
- Antibodies: indispensable tools for biomedical researchTrends in Biochemical Sciences, 2000
- PREDITOP: A program for antigenicity predictionJournal of Molecular Graphics, 1993
- Correlation between the location of antigenic sites and the prediction of turns in proteinsImmunology Letters, 1993
- [8] Predicting location of continuous epitopes in proteins from their primary structuresMethods in Enzymology, 1991
- Continuous and discontinuous protein antigenic determinantsNature, 1986
- Prediction of chain flexibility in proteinsThe Science of Nature, 1985
- Turns in Peptides and ProteinsAdvances in protein chemistry, 1985
- The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a proteinNature, 1984
- Correlation between segmental mobility and the location of antigenic determinants in proteinsNature, 1984
- Prediction of protein antigenic determinants from amino acid sequences.Proceedings of the National Academy of Sciences, 1981