CUSHING'S DISEASE: GROWTH HORMONE RESPONSE TO HYPOGLYCEMIA AFTER CORRECTION OF HYPERCORTISOLISM
- 1 January 1977
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 44 (1), 218-221
- https://doi.org/10.1210/jcem-44-1-218
Abstract
Growth hormone responses to insulin-induced hypoglycemia were studied in 17 patients with inactive Cushing's disease. A normal GH rise was found in 9 of 9 patients without evidence of progressive pituitary tumor after bilateral adrenalectomy and 3 of 4 patients after correction of hypercortisolism by transsphenoidal removal of pituitary microadenomas. In contrast, 3 of 4 patients with Nelson's syndrome had impaired GH responsiveness to hypoglycemia. These results show that GH responsiveness is normal in the majority of patients with inactive Cushing's disease and do not support the concept of a primary hypothalamic or central nervous system abnormality of GH regulation in Cushing's disease.Keywords
This publication has 3 references indexed in Scilit:
- Hypopituitarism After External IrradiationAnnals of Internal Medicine, 1975
- A FUNDAMENTAL DEFECT OF ADRENOCORTICAL CONTROL IN CUSHING'S DISEASEJournal of Endocrinology, 1968
- Glucose suppression of serum growth hormone in the diagnosis of acromegalyJAMA, 1967