Changes in the cardiac glutathione status after ischemia and reperfusion
- 1 January 1985
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 41 (1), 42-43
- https://doi.org/10.1007/bf02005863
Abstract
In the isolated and perfused rabbit heart ischemia induced a rapid decline of contractility, associated with a reduction of the content of tissue GSH with no significant changes in GSSG. Reperfusion induced a small recovery of contractility, a substantial release of total glutathione and a further decrease in the content of tissue GSH with a significant increase of tissue GSSG. Glutathione reductase and glutathione peroxidase activities were not affected by ischemia and reperfusion. This study suggests a possible role for glutathione in the determination of functional damage induced by myocardial ischemia and reperfusion.Keywords
This publication has 17 references indexed in Scilit:
- Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heartJournal of Molecular and Cellular Cardiology, 1980
- Glutathione peroxidase activity and release of glutathione from oxygen-deficient perfused rat heartBiochemical and Biophysical Research Communications, 1979
- Prolonged protective effect of propranolol on hypoxic heart muscleThe American Journal of Cardiology, 1978
- A Correlation between Glutathione Levels and Cellular Damage in Isolated HepatocytesEuropean Journal of Biochemistry, 1977
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976
- The occurrence of protein-bound mixed disulfides in rat tissuesBiochimica et Biophysica Acta (BBA) - Protein Structure, 1973
- Oxidation in the NADP system and release of GSSG from hemoglobin‐free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxidesFEBS Letters, 1972
- Measurement of oxidized glutathione and total glutathione in the perfused rat heartBiochemical Journal, 1970
- Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissuesAnalytical Biochemistry, 1969