A COMPARISON OF THE RESPIRATORY EFFECTS OF MEPTAZINAOL PENTAZOCINE AND MORPHINE
Open Access
- 1 June 1979
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 51 (6), 497-502
- https://doi.org/10.1093/bja/51.6.497
Abstract
The respiratory effects of a new strong analgesic, meptazinol, were compared with a placebo and with equianalgesic doses of morphine and pentazocine in a double-blind crossover trial in seven healthy volunteers. No significant change in the ventilatory response to rebreathing carbon dioxide was observed after meptazinol 100 mg/70 kg or placebo. However, both morphine 10 mg/70 kg and pentazocine 60 mg/70 kg depressed the slope of the ventilatory response ( — 30.0% and —31.6% respectively, P>0.02, averaged over the first 3.5-h period). End-tidal carbon dioxide tension (Pe‘co) while breathing room air increased significantly following all three drugs. However, the increase in Pe’qo, after meptazinol (0.22 kPa averaged over 3.5 h) was significantly less than that following morphine (0.40 kPa, P>0.05) and pentazocine (0.59 kPa, P>0.01). While breathing room air with a resistive inspiratory load of 8 kPa litre1 s, Pe‘co, again increased significantly (P>0.05) following all three drugs. The increase in Pe’co after meptazinol was then the same as that after morphine (0.51 kPa averaged over 3.5 h). The increase following pentazocine (0.80 kPa) was significantly greater than that after both morphine and meptazional(P>0.02).This publication has 3 references indexed in Scilit:
- Variability of ventilatory responses to hypoxia and hypercapniaJournal of Applied Physiology, 1977
- ANALGESIA AFTER OPERATION: A controlled comparison of meptazinol, pentazocine and pethidineBritish Journal of Anaesthesia, 1977
- CARBON-DIOXIDE RESPONSE LINES IN YOUNG-ADULTS - LIMITS OF NORMAL RESPONSEPublished by Elsevier ,1976