THE EFFECT OF PEPTONE ON CAPILLARY PERMEABILITY AND ITS NEUTRALIZATION BY ADRENAL CORTICAL EXTRACT

Abstract

Peptone induced an increase in permeability of the capillaries of the rabbit skin similar to that of leukotaxine. This capillary damaging factor of peptone, like that of leukotaxine, could be neutralized more or less completely by adrenal cortical extract. Corticosterone, compound E and anhydrohydroxy-progesterone did not have this effect. Certain differences in the reaction of corticosterone to peptone and to leukotaxine suggest that the action of peptone is not due to leukotaxine but to a leukotaxine-like substance.